| Formulary Chapter 5: Infections - Full Chapter
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| Notes: |
Where a formulary entry does not detail a medicine’s indications for use, the medicine can be assumed to be approved for all licensed indications.
Formulary approved "off-label" use is detailed separately.
This section advises on the choice of anti-infective agents available at each Trust. Doctors should refer to local or departmental antibiotic guidelines for advice regarding specific treatments within specialised units (including prophylaxis for surgical, medical and dental procedures). Different antibiotic policies can be found in different hospitals due to local variations in resistance and antibiotic susceptibility.
M: Use of this agent only to be initiated under the advice of a microbiologist or virologist as appropriate.
S: Use of this agent only to be initiated under the advice of a relevant clinical specialist. |
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| Chapter Links... |
 NICE CG54: Urinary tract infection in under 16s: diagnosis and management |
| NICE NG84: Sore throat (acute): antimicrobial prescribing |
| NICE NG89: Sinusitis (acute): antimicrobial prescribing |
| NICE NG91: Otitis media (acute): antimicrobial prescribing |
| Details... |
| 05.03.01 |
HIV infection |
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| 05.03.01 |
Nucleoside reverse transcriptase inhibitors |
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Abacavir tabs, oral solution
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Formulary
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Abacavir with lamiviudine (Kivexa®)
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Formulary
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Use generic preparation in preference
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Abacavir, lamivudine and zidovudine tabs (Trizivir®)
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Formulary
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Didanosine tabs, caps
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Formulary
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Dolutegravir, abacavir & lamivudine tabs (Triumeq®)
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Formulary
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MHRA Jun 18: Dolutegravir (Tivicay▼, Triumeq▼, Juluca▼): signal of increased risk of neural tube defects; do not prescribe to women seeking to become pregnant; exclude pregnancy before initiation and advise use of effective contraception
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Elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide tabs (Genvoya®)
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Formulary
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MHRA Apr 2019: Elvitegravir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1
MHRA Dec 2016: Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects
NHSE 16043/P: Clinical Commissioning Policy: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
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Emtricitabine caps, oral solution
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Formulary
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Emtricitabine with rilpivirine and tenofovir alafenamide tabs (Odefsey®)
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Formulary
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 NHSE 16043/P: Clinical Commissioning Policy: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
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Emtricitabine with tenofovir alafenamide tabs (Descovy®)
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Formulary
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NHSE 16043/P: Clinical Commissioning Policy: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
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Lamivudine tabs, oral solution
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Formulary
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Stavudine caps, oral solution
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Formulary
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Tenofovir disoproxil tabs (Viread®)
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Formulary
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Use generic preparations in preference
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NICE CG165: Hepatitis B (chronic) - incorporates TA173
NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
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Tenofovir disoproxil with cobicistat, elvitegravir and emtricitabine tabs (Stribild® )
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Formulary
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MHRA Apr 2019: Elvitegravir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1
MHRA Dec 2016: Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects
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Tenofovir disoproxil with emtricitabine and efavirenz tabs (Atripla®)
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Formulary
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Use generic preparation in preference
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Tenofovir disoproxil with emtricitabine and rilpivirine (Eviplera®)
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Formulary
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Tenofovir disoproxil with emtricitabine tabs (Truvada®)
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Formulary
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Use generic preparation in preference
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Zidovudine caps, oral solution (Retrovir®)
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Formulary
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Use generic preparations in preference
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Zidovudine with lamivudine tabs (Combivir®)
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Formulary
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Use generic preparations in preference
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Protease inhibitors |
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Non-nucleoside reverse transcriptase inhibitors |
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Other antiretrovirals |
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Pharmacokinetic enhancers of antiretrovirals |
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Combination Products |
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Key |
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Cytotoxic Drug
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Controlled Drug
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High Cost Medicine
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Cancer Drugs Fund
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NHS England |
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Homecare |
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CCG |
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Traffic Light Status Information
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Description |
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Specialist or hospital prescribing only.
The responsibility for prescribing, monitoring, dose adjustment and review should remain with the specialist or hospital.
In very exceptional circumstances a specialist may discuss individual patient need for a RED drug to be prescribed by a GP and the GP should consider informing the Medicines Management team before a decision is made to prescribe for individual patients.
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Treatment can be initiated in primary care after a recommendation from an appropriate specialist |
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Specialist initiation followed by maintenance prescribing in primary care |
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Specialist initiation with ongoing monitoring required. After dose stabilisation GPs can be requested to take over prescribing responsibilities using the approved APC shared care documentation |
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Specialist and non-specialist initiation |
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Not recommended for prescribing |
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