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 Formulary Chapter 5: Infections - Full Chapter
Notes:

Where a formulary entry does not detail a medicine’s indications for use, the medicine can be assumed to be approved for all licensed indications.

Formulary approved "off-label" use is detailed separately.

This section advises on the choice of anti-infective agents available at each Trust.  Doctors should refer to local or departmental antibiotic  guidelines for advice regarding specific treatments within specialised  units (including prophylaxis for surgical, medical and dental  procedures). Different antibiotic policies can be found in different  hospitals due to local variations in resistance and antibiotic  susceptibility.

M: Use of this agent only to be initiated under the advice of a  microbiologist or virologist as appropriate.

S: Use of this agent only to be initiated under the advice of a relevant clinical specialist.

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 Details...
05.03.01  Expand sub section  HIV infection
05.03.01  Expand sub section  Nucleoside reverse transcriptase inhibitors
Abacavir tabs, oral solution
View adult BNF View SPC online
Formulary
Red
High Cost Medicine
 
   
Abacavir with lamiviudine (Kivexa)
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Formulary
Red
High Cost Medicine

Use generic preparation in preference

 
   
Abacavir, lamivudine and zidovudine tabs (Trizivir)
View adult BNF View SPC online
Formulary
Red
High Cost Medicine

 
   
Didanosine tabs, caps
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Formulary
Red
High Cost Medicine
 
   
Dolutegravir, abacavir & lamivudine tabs (Triumeq)
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Formulary
Red
High Cost Medicine

 
Link  MHRA Jun 18: Dolutegravir (Tivicay▼, Triumeq▼, Juluca▼): signal of increased risk of neural tube defects; do not prescribe to women seeking to become pregnant; exclude pregnancy before initiation and advise use of effective contraception
   
Elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide tabs (Genvoya)
View adult BNF View SPC online
Formulary
Red
High Cost Medicine

 
Link  MHRA Apr 2019: Elvitegravir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1
Link  MHRA Dec 2016: Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects
Link  NHSE 16043/P: Clinical Commissioning Policy: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
   
Emtricitabine caps, oral solution
View adult BNF View SPC online
Formulary
Red
High Cost Medicine
 
   
Emtricitabine with rilpivirine and tenofovir alafenamide tabs (Odefsey)
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Formulary
Red
High Cost Medicine

 
Link  NHSE 16043/P: Clinical Commissioning Policy: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
   
Emtricitabine with tenofovir alafenamide tabs (Descovy)
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Formulary
Red
High Cost Medicine

 
Link  NHSE 16043/P: Clinical Commissioning Policy: Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
   
Lamivudine tabs, oral solution
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Formulary
Red
High Cost Medicine
 
   
Stavudine caps, oral solution
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Formulary
Red
High Cost Medicine
 
   
Tenofovir disoproxil tabs (Viread)
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Formulary
Red
High Cost Medicine

Use generic preparations in preference

 
Link  NICE CG165: Hepatitis B (chronic) - incorporates TA173
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
   
Tenofovir disoproxil with cobicistat, elvitegravir and emtricitabine tabs (Stribild )
View adult BNF View SPC online
Formulary
Red
High Cost Medicine

 
Link  MHRA Apr 2019: Elvitegravir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1
Link  MHRA Dec 2016: Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects
   
Tenofovir disoproxil with emtricitabine and efavirenz tabs  (Atripla)
View adult BNF View SPC online
Formulary
Red
High Cost Medicine

Use generic preparation in preference

 
   
Tenofovir disoproxil with emtricitabine and rilpivirine (Eviplera)
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Formulary
Red
High Cost Medicine

 
   
Tenofovir disoproxil with emtricitabine tabs  (Truvada)
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Formulary
Red
High Cost Medicine

Use generic preparation in preference

 
   
Zidovudine caps, oral solution (Retrovir)
View adult BNF View SPC online
Formulary
Red
High Cost Medicine

Use generic preparations in preference

 
   
Zidovudine with lamivudine tabs (Combivir)
View adult BNF View SPC online
Formulary
Red
High Cost Medicine

Use generic preparations in preference

 
   
05.03.01  Expand sub section  Protease inhibitors
05.03.01  Expand sub section  Non-nucleoside reverse transcriptase inhibitors
05.03.01  Expand sub section  Other antiretrovirals to top
05.03.01  Expand sub section  Pharmacokinetic enhancers of antiretrovirals
05.03.01  Expand sub section  Combination Products
 ....
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Specialist or hospital prescribing only. The responsibility for prescribing, monitoring, dose adjustment and review should remain with the specialist or hospital. In very exceptional circumstances a specialist may discuss individual patient need for a RED drug to be prescribed by a GP and the GP should consider informing the Medicines Management team before a decision is made to prescribe for individual patients.   

Amber 1

Treatment can be initiated in primary care after a recommendation from an appropriate specialist  

Amber 2

Specialist initiation followed by maintenance prescribing in primary care  

Amber 3

Specialist initiation with ongoing monitoring required. After dose stabilisation GPs can be requested to take over prescribing responsibilities using the approved APC shared care documentation  

Green

Specialist and non-specialist initiation  

Grey

Not recommended for prescribing  

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