South East London Joint Medicines Formulary Formulary

	South East London Joint Medicines Formulary
	Guy's and St Thomas' NHS Foundation Trust Kings College Hospital NHS Foundation Trust Lewisham and Greenwich NHS Trust

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Formulary Chapter 2: Cardiovascular system - Full Chapter

Notes:

Where a formulary entry does not detail a medicine’s indications for use, the medicine can be assumed to be approved for all licensed indications.

Formulary approved "off-label" use is detailed separately.

Chapter Links...

NICE NG106: Chronic heart failure in adults: diagnosis and management

SE London APC guidance: optimising therapy in chronic stable angina

SE London APC Guidance: Pharmacological management of Heart Failure

Details...

02.08.02

Oral anticoagulants

Acenocoumarol tabs

Formulary

Apixaban tabs

Formulary

Amber Traffic Light For treatment and secondary prevention of DVT and PE, and thromboprophylaxis in AF.

See links at the end of the section for initiation of treatment and transfer of care documents

Red Traffic Light (hospital only) For prevention of VTE after hip or knee replacement surgery

SE London APC prescribing guidance - Apixaban for AF

SE London APC prescribing guidance - Apixaban for VTE

NICE TA245: Venous thromboembolism - apixaban (hip and knee surgery

NICE TA275: Stroke and systemic embolism (prevention, non-valvular atrial fibrillation) - apixaban

NICE TA341: Apixaban for treatment and secondary prevention of DVT and/or PE

Apixaban for non-valvular AF - manufacturers patient information booklets (several languages)

Apixaban for venous thromboembolism - manufaturers patient information booklets (several languages)

Dabigatran caps

Formulary

Amber Traffic Light For treatment and secondary prevention of DVT and PE, and thromboprophylaxis in AF

See links at the end of the section for initiation of treatment and transfer of care documents

Red Traffic Light (hospital only) For prevention of VTE after hip or knee replacement surgery

SE London APC prescribing guidance: Dabigatran for AF

SE London APC prescribing guidance: Dabigatran for VTE

NICE TA157: Venous thromboembolism - dabigatran

NICE TA249: Dabigatran for Stroke prevention in AF

NICE TA327: Dabigatran for treatment and secondary prevention of DVT and/or PE

Edoxaban tabs

Formulary

See links at the end of the section for initiation of treatment and transfer of care documents

SE London APC prescribing guidance: Edoxaban for AF

SE London APC prescribing guidance: Edoxaban for VTE

NICE TA354: Edoxaban for treating and for preventing DVT and/or PE

NICE TA355: Edoxaban for thromboprohylaxis in non-valvular AF

Edoxaban - manufacturer’s patient support materials (several languages)

Phenindione tabs

Formulary

Rivaroxaban tabs (licensed uses)

Formulary

Amber Traffic Light For treatment and secondary prevention of DVT and PE, thromboprophylaxis in AF, and preventing adverse outcomes after acute management of ACS.

See links at the end of the section and below for initiation of treatment and transfer of care documents

Red Traffic Light (hospital only) For prevention of VTE after elective hip or knee replacement surgery

Rivaroxaban for ACS: Notification of initiation to GP

Rivaroxaban in ACS: Transfer of care to GP

SE London prescribing guidance: Rivaroxaban for ACS

SE London prescribing guidance: Rivaroxaban for AF

SE London prescribing guidance: Rivaroxaban for VTE

NICE TA256: Rivaroxaban for thromboprophylaxis in AF

NICE TA261: Rivaroxaban for the treatment of DVT and prevention of recurrent DVT and/or PE

NICE TA287: Rivaroxaban for treating PE and preventing recurrent VTE

NICE TA335: Rivaroxaban for preventing adverse outcomes after acute management of ACS

Rivaroxaban - manufacturer’s patient brochures (several languages)

Warfarin tabs

Formulary

Rivaroxaban tabs (orthopaedic off label use)

Formulary

Approved off-label indication:

Thromboprophylaxis post pelvic ring/acetabular fracture as an alternative to Low Molecular Weight Heparin Full course of up to 90 days to be prescribed and provided by the hospital. Dose as per thromboprophylaxis post elective orthopaedic surgery (10mg daily)

SE London APC Recommendation: Rivaroxaban for thromboprophylaxis post pelvic ring fracture

Direct Oral Anticoagulants (DOACs) for VTE: Notification of initiation to GP

Direct Oral Anticoagulants (DOACs) for VTE: Transfer of care to GP form

Direct Oral Anticoagulants (DOACs) in AF: Notification of initiation to GP

Direct Oral Anticoagulants (DOACs) in AF: Transfer of Care to GP

SE London APC - Calculating creatinine clearance for DOACs

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Key

	Notes
	Section Title (top level)
	Section Title (sub level)
	First Choice item
	Non Formulary section
	Restricted Drug
	Unlicensed
	Display tracking information
	Link to adult BNF
	Link to SPCs
	Scottish Medicines Consortium

	Cytotoxic Drug
	Controlled Drug
	High Cost Medicine
	Cancer Drugs Fund
	NHS England
	Homecare
	CCG

Traffic Light Status Information

Status	Description
	Specialist or hospital prescribing only. The responsibility for prescribing, monitoring, dose adjustment and review should remain with the specialist or hospital. In very exceptional circumstances a specialist may discuss individual patient need for a RED drug to be prescribed by a GP and the GP should consider informing the Medicines Management team before a decision is made to prescribe for individual patients.
	Treatment can be initiated in primary care after a recommendation from an appropriate specialist
	Specialist initiation followed by maintenance prescribing in primary care
	Specialist initiation with ongoing monitoring required. After dose stabilisation GPs can be requested to take over prescribing responsibilities using the approved APC shared care documentation
	Specialist and non-specialist initiation
	Not recommended for prescribing