netFormulary South East London Joint Medicines Formulary NHS
Guy's and St Thomas' NHS Foundation Trust
Kings College Hospital NHS Foundation Trust
Lewisham and Greenwich NHS Trust
 Formulary Chapter 10: Musculoskeletal and joint diseases - Full Chapter
10.01.04  Expand sub section  Gout and cytotoxic-induced hyperuricaemia
10.01.04  Expand sub section  Acute attacks of gout
10.01.04  Expand sub section  Long-term control of gout
10.01.04  Expand sub section  Hyperuricaemia associated with cytotoxic drugs
Rasburicase injection
View adult BNF View SPC online
High Cost Medicine
Anakinra injection
View adult BNF View SPC online
Restricted Drug Restricted
High Cost Medicine
Approved off-label indication (consultant specialists only): Polyarticular acute gout and multiple swollen joints where:
  • There have been recurrent acute flares of gout
  • There has been lack of response to, or contra-indications to NSAIDs, colchicine and steroids Dose = 100mg daily for 3 days 
  • Link  SE London APC recommendation: anakinra for acute gout
    Probenecid tabs
    Unlicensed Drug Unlicensed Approved for:
  • Prevention of nephrotoxicity associated with cidofovir
  • Prophylaxis of gout in cases resistant to allopurinol 
    Probenecid tabs (penicillin augmentation in syphilis)
    Unlicensed Drug Unlicensed
    Approved for use in:
  • Late latent syphilis and neurosyphilis in conjuction with penicillin treatments (either amoxicillin or procaine pneicillin G) as per BASHH guidance. Dose = 500mg qds for duration of penicillin use 
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Track Changes
    Display tracking information
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    Link to adult BNF
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    Link to SPCs
    Scottish Medicines Consortium
    Cytotoxic Drug
    Cytotoxic Drug
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHS England

    Traffic Light Status Information

    Status Description


    Specialist or hospital prescribing only. The responsibility for prescribing, monitoring, dose adjustment and review should remain with the specialist or hospital. In very exceptional circumstances a specialist may discuss individual patient need for a RED drug to be prescribed by a GP and the GP should consider informing the Medicines Management team before a decision is made to prescribe for individual patients.   

    Amber 1

    Treatment can be initiated in primary care after a recommendation from an appropriate specialist  

    Amber 2

    Specialist initiation followed by maintenance prescribing in primary care  

    Amber 3

    Specialist initiation with ongoing monitoring required. After dose stabilisation GPs can be requested to take over prescribing responsibilities using the approved APC shared care documentation  


    Specialist and non-specialist initiation  


    Not recommended for prescribing